Heal without scars, scientists know how to get it!

Is it possible to heal without scars, and for our skin to look the same in its entirety, even if we have suffered wounds or burns? A group of scientists are working on it, we explain it to you.

Heal without scars, scientists know how to get it!

Scars are part of our life: everyone, in some moment, we have fallen and broken our skin, and some more than others, we have formed those marks that indicate that the skin has been reborn where it was damaged.We explain in a previous post all about the scars, and we talked about complex and natural process that the skin puts into operation every time it is injured.

This scar healing without scarring, skill that humans-and mammals in general- we don't have and rather it characterizes amphibians and fish, it is becoming a real possibility thanks to a group of scientists from the University of Pennsylvania, which in turn have been based ado in a study of several years of the Laboratory for Development and Regenerative Biology, of the University of Irvine (California); both teams investigate how heal the skin and make it look exactly the same .

As you know, fat cells-or adipocytes -are all the skin, but when we cut ourselves and the healing begins, the skin that arises has no adipocytes or hair follicles; the skin of a scar is full of myofibroblasts , specialized healing cells, so when we get hurt and the skin regenerates, it looks less elastic, maybe rough, sometimes white and without hairs (if you've ever hurt your head and you have a scar, you'll see that you don't grow hair).

Heal without scars, scientists know how to get it!

The point of this research is the manipulation of myofibroblasts : influence the development of these cells when the healing begins so that they become adipocytes.But they discovered that the hair follicles must first be regenerated, and that from them and in response, the fatty tissue will come out.In previous research , it was shown that both adipocytes and hair follicles develop separately, but not independently, and that and the latter are always born first.

The team suspected that hair follicles support the growth of sebaceous cells in the process of skin regeneration, and one of the first experiments was to induce growth of hair follicles in myofibroplasts, that is, in scar tissue; they did this in mice and human skin samples grown in the laboratory.

One of the findings was the discovery that the follicles release a signal protein (the protein bone morphogenetic ), just when they begin to form, and this protein is what converts myofibroblasts into adipocytes; that is, this is where metamorphosis came true, and what has opened a window to science to heal without scars.

Under this, if hair follicle growth were induced in a wounded in the process of healing, the resulting skin would be indistinguishable from the preexisting one. George Cotsarellis , one of the researchers, says:

“It was generally thought that myofibroblasts were unable to become a different type of cell.However, our research shows that we have the ability to influence them, and that this influence can be perfectly capable and stable to convert them into adipocytes."

This research was recently published in the journal Science .It is hardly a possibility, because what has been done are laboratory studies; A different thing is to generate the growth of hair follicles in a wound of a living human being.If the team is able to replicate these trials in humans, it could lead to a totally new territory: scarring without scars would mean a huge advance for the burns, for example, as there would be no differentiation between the old and the new skin.

A new and wide field has been opened to science, because until now scientists thought that the transformation of myofibroblasts into adipocytes It was biologically impossible in mammals.Will we be on the path of science fiction?

If you are interested in these topics, read about Sweden's cyborgs group, or DARPA creates ultrasound mind control technology.

Images: chaim zvi, gaelx, Laura Lewis

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